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Updates found with 'disorder'

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Updates found with 'disorder'

Recommendations for Wilson disease: 1. WD should be considered in any individual between the ages of 3 and 55 years with liver abnormalities of uncertain cause. Age alone should not be the basis for eliminating a diagnosis of WD (Class I, Level B). 2. WD must be excluded in any patient with unexplained liver disease along with neurological or neuropsychiatric disorder (Class I, Level B). 3. In a patient in whom WD is suspected, Kayser-Fleischer rings should be sought by slit-lamp examination by a skilled examiner. The absence of Kayser-Fleischer rings does not exclude the diagnosis of WD, even in patients with predominantly neurological disease (Class I, Level B). 4. An extremely low serum ceruloplasmin level (<50 mg/L or <5 mg/dL) should be taken as strong evidence for the diagnosis of WD. Modestly subnormal levels suggest further evaluation is necessary. Serum ceruloplasmin within the normal range does not exclude the diagnosis (Class I, Level B). 5. Basal 24-hour urinary excretion of copper should be obtained in all patients in whom the diagnosis of WD is being considered. The amount of copper excreted in the 24-hour period is typically >100 _g (1.6_mol) in symptomatic patients, but finding >40 _g (>0.6 _mol or >600 nmol) may indicate WD and requires further investigation (Class I, Level B). 6. Penicillamine challenge studies may be performed for the purpose of obtaining further evidence for the diagnosis of WD in symptomatic children if basal urinary copper excretion is <100 _g/24 hours (1.6_mol/24 hours). Values for the penicillamine challenge test of >1600_g copper/24 hours (>25_mol/24 hours) following the administration of 500 mg of D-penicillamine at the beginning and again 12 hours later during the 24-hour urine collection are found in patients with Wilson disease. The predictive value of this test in adults is unknown (Class I, Level B). 7. Hepatic parenchymal copper content >250 _g/g dry weight provides critical diagnostic information and should be obtained in cases where the diagnosis is not straightforward and in younger patients. In untreated patients, normal hepatic copper content (<40-50 _g/g dry weight) almost always excludes a diagnosis of WD. Further diagnostic testing is indicated for patients with intermediate copper concentrations (70-250 _g/g dry weight) especially if there is active liver disease or other symptoms of WD (Class I, Level B). 8. Neurologic evaluation and radiologic imaging of the brain, preferably by MR imaging, should be considered prior to treatment in all patients with neurologic WD and should be part of the evaluation of any patient presenting with neurological symptoms consistent with WD (Class I, Level C). 9. Mutation analysis by whole-gene sequencing is possible and should be performed on individuals in whom the diagnosis is difficult to establish by clinical and biochemical testing. Haplotype analysis or specific testing for known mutations can be used for family screening of first-degree relatives of patients with WD. A clinical geneticist may be required to interpret the results (Class I, Level B). 10. Patients in the pediatric age bracket who present a clinical picture of autoimmune hepatitis should be investigated for WD (Class I, Level B). 11. Adult patients with atypical autoimmune hepatitis or who respond poorly to standard corticosteroid therapy should also be investigated for WD (Class I, Level C). 12. WD should be considered in the differential diagnosis of patients presenting with nonalcoholic fatty liver disease or have pathologic findings of nonalcoholic steatohepatitis (Class IIb, Level C). 13. WD should be suspected in any patient presenting with acute hepatic failure with Coombs-negative intravascular hemolysis, modest elevations in serum aminotransferases, or low serum alkaline phosphatase and ratio of alkaline phosphatase to bilirubin of <2 (Class I, Level B). 14. First-degree relatives of any patient newly diagnosed with WD must be screened for WD (Class I, Level A). 15. Initial treatment for symptomatic patients should include a chelating agent (D-penicillamine or trientine). Trientine may be better tolerated (Class I, Level B). 16. Patients should avoid intake of foods and water with high concentrations of copper, especially during the first year of treatment (Class I, Level C). 17. Treatment of presymptomatic patients or those on maintenance therapy can be accomplished with a chelating agent or with zinc. Trientine may be better tolerated (Class I, Level B). 18. Patients with acute liver failure due to WD should be referred for and treated with liver transplantation immediately (Class I, Level B). 19. Patients with decompensated cirrhosis unresponsive to chelation treatment should be evaluated promptly for liver transplantation (Class I, Level B). 20. Treatment for WD should be continued during pregnancy, but dosage reduction is advisable for Dpenicillamine and trientine (Class I, Level C). 21. Treatment is lifelong and should not be discontinued, unless a liver transplant has been performed (Class I, Level B). 22. For routine monitoring, serum copper and ceruloplasmin, liver biochemistries and international normalized ratio, complete blood count and urinalysis (especially for those on chelation therapy), and physical examination should be performed regularly, at least twice annually. Patients receiving chelation therapy require a complete blood count and urinalysis regularly, no matter how long they have been on treatment (Class I, Level C). 23. The 24-hour urinary excretion of copper while on medication should be measured yearly, or more frequently if there are questions on compliance or if dosage of medications is adjusted. The estimated serum non–ceruloplasmin bound copper may be elevated in situations of nonadherence and extremely low in situations of overtreatment (Class I, Level C).
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How to Evaluate and Treat Dyspepsia?For a healthy body, proper digestion and absorption of food is very important. The digestion is an extremely intricate process and involves many organs. Impairment in any of the organs can hamper the digestive process, leading to a very common condition called dyspepsia. It is caused by malfunction of one of the muscular organs along the digestive tract including esophagus, stomach, small and large intestines and colon.Causes: While dyspepsia is more a symptom, there are various reasons that lead to it including gastritis, peptic ulcer disease, infections, motility disorders, gastroesophageal reflux disease (GERD), cancers of the digestive tract or any other abnormality in the digestive tract.Evaluation: When a patient has chronic dyspepsia or indigestion, the first thing to do is a thorough evaluation to find out the underlying cause. As noted above, there are functional and nonfunctional causes leading to dyspepsia. While gastric ulcers or polyps are visible during an endoscopy, conditions like gastritis and malignancy can only be diagnosed under microscopic examinations.Some of the tests that are used for evaluation of the cause of dyspepsia include:1. X-ray: Any growth would be visible on an x-ray and further testing can then be done to confirm the exact nature of it.2. Endoscopy: This will allow the doctor to see the actual digestive tract and identify any structural abnormalities or growth.3. Colonoscopy: If the problem is suspected to be in the lower gastrointestinal tract, then a colonoscopy may be in indicated.4. Gastric emptying study: This study can also reveal the abnormalities in the digestive tract5. Culture: Dyspepsia caused by Helicobacter pylori can be diagnosed through cultures of the stomach contents.Treatment: The treatment of dyspepsia is quite complicated and cannot be clearly outlined given the various conditions that it is associated with. Even specific foods can induce indigestion in some people. Therefore, a multipronged approach is required to treat dyspepsia.Education: The affected person should be educated about the non-life-threatening nature of the problem and its chronicity. Some of the drugs used in treatment include:1. Proton pump inhibitors: These reduce the amount of acid produced in the stomach and thereby help in relieving symptoms.2. Promotility drugs: They improve the movement of the muscles in the intestinal tract and are so used in managing dyspepsia.3. Antibiotics: If an infection is suspected, antibiotics are effective.4. Smooth muscle relaxants: Drugs like hyoscyamine and methscopolamine have been shown to provide relief in some patients.5. Psychotropic drugs: Anxiety and depression are frequently seen in people with dyspepsia, and managing these can help reduce the dyspepsia.As noted, the causes, symptoms, and management are very specific to individuals and needs to be managed by the doctor.
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GERDOVERVIEWThe Gastroesophageal reflux is commonly known as Acid reflux. It is a chronic digestive disorder wherein the stomach acids or contents flow back into the esophagus. The disease is characterized by a burning sensation in the chest region, chest pain, difficulty in swallowing, dry cough and lumpy sensation in the throat. The disease is easily mistaken with heartburn due to the similarity of symptoms.In most cases, people can overcome the effects of acid reflux in the natural course. However, in certain cases medical attention and treatment is necessary. People who are more likely to develop the disease include those with obesity issues, smoking habit, diabetes and constipation.Chronic occurrence of the disease in due course could lead to a narrowing of the esophagus or result in sores of the esophagus. In some extreme cases acid reflux could culminate in esophageal cancer, the occurrence of which is considerably low.SYMPTOMSThe common symptoms of Acid Reflux can be enumerated as the following• Burning sensation in the chest area• Problems in swallowing• Dry cough• Lumpiness in the throat• Regurgitation of foodCAUSES & RISK FACTORSLifestyle factors play a critical role in the incidence of acid reflux. Factors such as obesity, excessive weight gain and smoking greatly increase the risk while pre-existing health conditions frequent constipation, diabetes, asthma and others also add to the risk.ComplicationBleedingStrictureRespiratory symptoms not responding to treatmentBarrets esophagus CancerDiagnosisUGI Endoscopy (Painless)PH monitoringManometry
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